The issue of heat transfer is one of the most important issues that can cause many challenges in many cases if it is not investigated properly. In recent years, studies on the rheological behavior and heat transfer of nanofluids have increased greatly, and many researchers have conducted research in this field, and the results indicate significant progress in this field. This research deals with the numerical investigation of heat transfer and pressure drop of nanofluid flow with water base fluid and ethylene glycol water mixture with aluminum oxide and copper oxide nanoparticles. In order to increase heat transfer as much as possible, in addition to using suitable nanofluid, a tube with an axially symmetrical sinusoidal wall can also be used. In this article, a numerical investigation for base fluids and nanofluids with different volume concentrations and different nanoparticle diameters inside a smooth and sinusoidal tube has been done and the results have been presented.