One of the serious problems in the production and transportation of crude oil is the formation of wax and its accumulation in the transmission pipelines. The formation and accumulation of wax deposits causes problems such as blockage of pipelines and operational equipment, which will increase the pressure drop, increase the viscosity of the liquid, and then increase the pumping costs. In addition, stopping the process in order to remove and clean the deposited wax will cause a lot of costs to the production unit. In order to reduce the accumulation of wax deposits in crude oil pipelines, several methods have been used, among them, the continuous injection of wax reforming inhibitors has been evaluated as an alternative attraction. In this research, in order to investigate the effect of inhibitors on wax accumulation, molecular simulation was used and their results and performance were studied by radial distribution function (RDF) analysis. In this simulation, the effect of ethylene vinyl acetate (EVA) and polyoctadecyl methacrylate (PODMA) inhibitors on wax accumulation was studied separately. The results of the graph (RDF) showed that the used inhibitors have a good performance in reducing wax accumulation or delaying it. When using the inhibitor (EVA), the best inhibition performance was EVA3 with 13.3% by weight and g(r) value 1.5, and when using the inhibitor (PODMA), comparing the results showed that PODMA2 with 24.5% by weight And g(r) value of 3 performs best.